Who: Louisville (0-2) at No. 9 Clemson (2-0)
When: Thursday, 7:30 p.m.
Where: Papa John’s Cardinal Stadium (55,000) | Louisville, Ky.
Radio: Clemson Radio Network (WQSC-AM 1340 in Charleston) | Affiliates
What to know about Louisville: The Cardinals lost 31-24 in the Chick-Fil-A Kickoff Classic to Auburn, when it appeared head coach Bobby Petrino mishandled his timeouts in the final minute trying to get the ball back, and lost 34-31 at home to Houston when the Cards twice couldn’t hang on to a fourth-quarter lead ... Bobby Petrino is 11-3 in his Louisville coaching career after a loss, and that includes the Auburn and Houston losses. (The Cards lost their 2014 Belk Bowl to Georgia.) ... Clemson defensive coordinator Brent Venables will have to check the tape on numerous Louisville quarterbacks, since the Cardinals can’t name a definitive starter after two games. “That’s a great question. It’s something I can’t answer right now.” ... freshman Lamar Jackson (26-47, 268 yards, TD, 3 INT), sophomore Kyle Bolin (10-18, 157 yards, TD) and sophomore Reggie Bonnafon (8-13, 67 yards) have all been tried out at the quarterback position. Louisville’s team passer rating of 110.2 is currently the worst in the ACC ... four different receivers have eight receptions, including three freshmen ... safety Josh Harvey-Clemons, who transferred from Georgia after being on the business end of Auburn’s Prayer at Jordan-Hare in 2013, leads the team with 24 tackles and two interceptions ... Louisville’s defense has had the most success against Clemson sophomore quarterback Deshaun Watson, holding Watson to 2-of-6 passing for minus-5 yards and an interception last year before leaving with a broken bone in his hand.
When last they met: Clemson 23, Louisville 17 on Oct. 11, 2014 in Clemson: Just read the recap. Kinda says it all.
All-time series: Clemson leads 1-0
Which Clemson Tiger is licking his chops: Junior safety Jayron Kearse, who’s got the bark and the bite of Clemson’s defense (No. 12 nationally in scoring defense), has eight tackles, a couple pass deflections and a momentum-shifting red-zone interception from Saturday’s win over Appalachian State. He also saved last year’s Louisville game by tracking down James Quick in the final two minutes.
Who’s keeping the Clemson coaches up at night: Junior linebacker Keith Kelsey, who has 23 tackles, four for a loss and two sacks thus far. He and James Burgess give the Cardinals a fierce linebacking bunch that’ll make life tough for Clemson running back Wayne Gallman and confusing for Watson.
Extra point: Louisville is 0-2 for the first time since 1998. The Cards have not been 0-3 since 1984.