The Highway 21 Drive-In is open year-round in the city of Beaufort. Operating since 1978, this two-screen drive-in is just off the Spanish Moss Trail and near Marine Corps Air Station.
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South Carolina has three drive-in movie theaters about an hour outside of the major cities in the state. They include the Highway 21 Drive-In in Beaufort, the Big Mo in Monetta and the 25 Drive-In Auto Theatre in Greenwood.