JAMES ISLAND -- A woman was taken to a Georgia burn center with life-threatening injuries Tuesday after firefighters pulled her from a burning home.

Firefighters responded to a home at 301 Howle Ave. just off Maybank Highway about 3 a.m. and found parts of the home engulfed in flames, James Island Fire Chief Chris Seabolt said.

Two men made it out of the house, but a woman confined to a wheelchair was still inside. Seabolt said James Island and Charleston firefighters found her inside a bedroom and removed her through the bedroom window.

The woman and her husband were taken to the Joseph M. Still Burn Center in Augusta for burns suffered in the fire. He had burns on his feet, authorities said.

The couple's grandson was at Medical University Hospital for smoke inhalation, firefighters said.

Seabolt said the rear of the house had significant damage.

The cause is under investigation. Seabolt said it doesn't appear suspicious at this time, but the Charleston County Sheriff's Office has been called to investigate because of the severity of the injuries.

St. John's firefighters also responded to the fire.

Reach Andy Paras at 937-5589 or on twitter at twitter.com/andyparas.