Nancy Humphries O'Dell has been very busy since leaving the anchor desk at WCBD-TV in Charleston.

She spends her days balancing motherhood with reporting entertainment news as co-anchor of the TV show 'Access Hollywood' and supporting philanthropic endeavors close to her heart.

This weekend, O'Dell will co-host the Jerry Lewis MDA Telethon broadcast on WCSC from 9 p.m. Sunday to 6:30 p.m. Monday.

It's been 16 years since O'Dell sat on the Channel 2 anchor desk, but the Myrtle Beach native says she's still nostalgic for Charleston. She visits whenever she can and hopes to retire here one day with her family.

She says she misses the 'friendly Southernness' the most and the community feel of going to the grocery store and maybe seeing someone you know. 'L.A. is so spread out, too big and the chances of that happening are next to none.'

O'Dell still keeps in touch with a lot of friends she met while living here.

'To this day, probably some of my best girlfriends are those that I met in Charleston — and my high school friends.'

Among her many philanthropic endeavors, including serving with the American Red Cross Celebrity Cabinet, O'Dell is a national vice president of the Muscular Dystrophy Association and an ALS national ambassador. Her mother and best friend, Betty Humphries, died from complications related to ALS in 2008.

Last month, O'Dell's family, along with the MDA, formed a foundation in honor of her mother called Betty's Battle: Fighting ALS.

For information about this weekend's telethon, visit MDA.org or www.wcsc.com.