It’s the “Prevent D” the New Orleans Saints might wish they’d had in place of defensive coordinator Gregg Williams and head coach Sean Payton. D-3, we mean, the disease-blocking vitamin that keeps you healthy, maybe not wealthy, but definitely wise.

D-3’s immune-regulating powers can D-feat brain-destroying amyloid tangles that contribute to Alzheimer’s mental deterioration. While we await human trials of bexarotene (the skin-cancer drug that Case Western University researchers discovered can activate removal of Alzheimer’s plaques in mice), we YOU Docs hope you keep “Prevent D” in your brain-boosting playbook.

Eating fresh vegetables and fruit, 100 percent whole grains and lean proteins (especially omega-3/DHA-rich fish, such as salmon and trout) are great ways to get heart-protecting, brain-enhancing, cancer-fighting vitamins. But that may not be enough. Half of adults are D-ficient.

If you’re typical, you’re probably sun D-prived -- spending 90 percent of your time indoors, and when you’re outside, you slather on high-SPF sunscreen. Add to that other D-blockers, such as having dark skin, being overweight, having diabetes or kidney disease, PLUS not eating D-rich foods, and YOU definitely need a D-3 supplement.

To make sure you get enough: Spend 15-30 minutes a day from 10 a.m. to 3 p.m. (using a sunscreen with an SPF of 8 or less) in the sun.

Take in 1,000 IU of D-3 a day from food or a supplement; 2,000 IU max without talking with your doc.

That’s a “Prevent D” that would make any NFL commissioner proud.

Mehmet Oz, M.D. is host of “The Dr. Oz Show,” and Mike Roizen, M.D. is Chief Medical Officer at the Cleveland Clinic Wellness Institute. For more information go to www.RealAge.com.