Two southbound lanes on Coleman Boulevard were blocked at 4 p.m. after a wreck near Northcutt Boulevard, according the Mount Pleasant police.
The department posted a photo of two badly damaged cars in its twitter account.
Two people got away with only minor injuries, according to Charleston County EMS Director Don Lundy.
The accident was cleared and the roadway reopened around 4:35 p.m., Mount Pleasant police said in a tweet.
Reach Dave Munday at 937-5553.