TV series hopeful "Identity" will make its best pitch to Hollywood with a first episode being filmed in Charleston.
The drama includes life-threatening illness, high society privilege and cloak-and-dagger intrigue.
Leading lady Ahna O'Reilly plays a New Yorker in need of an organ transplant whose only living relative, her half-brother Davis, is the son of a wealthy and powerful Charleston family.
"She connects with them only to find they're the target of a CIA investigation for involvement in domestic terrorism, and the agency wants her as their newest informant," the Deadline Hollywood website reports.
CBS Television Studios confirmed Friday that the show is filming here, but declined further comment.
"We don't talk specifics on pilot production because our sets are closed," said Lauri Metrose, senior vice-president for communications.
The CW Television Network ordered a pilot episode of "Identity" as part of its evaluation of the show. Broadcast networks make dozens of trial episodes before selecting a handful of new shows for their fall schedules.
O'Reilly is known for her work in the independent film hit "Fruitvale Station" and the Oscar-nominated motion picture "The Help."
Matt Barr, the male lead actor, played the title character in Lifetime's "Romeo Killer: The Chris Porco Story," Deadline Hollywood reports.
"Identity" could follow the success of "Reckless," a legal drama set in Charleston that was added to the CBS line-up after a pilot episode was filmed here. When the series will debut has not been announced.
Charleston-based "Army Wives" airs its final episode on March 16 after a seven-year run on Lifetime that pumped millions of dollars into the local economy.
In addition, new reality shows such as "Southern Charm" are made here.