A missing man may have run from a wreck on the Don Holt Bridge early Sunday morning, according to the Charleston County Sheriff’s Office.

James Matthew Brown, 38, of Brown Pelican Drive in Wando was reported missing Tuesday. A friend said he had not seen Brown since about 4 p.m. Saturday at the Big Game Bar & Grill on Belle Station Boulevard in Mount Pleasant, according to an incident report. Brown was driving a 2010 black Toyota Tundra.

Witnesses said a man ran after a wreck on the Don Holt Bridge about 1 a.m. Sunday. The truck that wrecked was Brown’s, Sheriff’s Capt. Eric Watson said.

Brown has brown hair and beard, hazel eyes, is 5 feet 11 inches tall and weighs 185 pounds, according to deputies.

Family and friends say he may have possible medical issues, Watson said.

Anyone with information is asked to call the Sheriff’s Office at 202-1700.