LOS ANGELES — Iron Man reigns as the standard-bearer of Hollywood superheroes with a $175.3 million domestic opening weekend for his latest sequel and an overseas haul of a half-billion dollars in less than two weeks.

According to studio estimates Sunday, “Iron Man 3” has raced to a worldwide total of $680.1 million. That includes $175.9 million in its second weekend overseas, where the film has rung up $504.8 million so far.

No other solo superhero — not even Batman or Spider-Man — has managed this kind of business.

“Iron Man 3” had the second-biggest domestic debut ever, behind the $207.4 million start over the same weekend last year for “The Avengers,” which teamed Robert Downey’s Stark with other Marvel Comics heroes. The new sequel surpassed the $169.2 million opening for 2011’s “Harry Potter” finale, the previous second-place debut.

“Iron Man 3” did four times the domestic business of every other movie out there; the combined total of all other releases was $43.7 million, according to Hollywood.com.